Identification of SPOCK2 as a Susceptibility Gene for Bronchopulmonary Dysplasia.
Bronchopulmonary dysplasia BPD represents the main respiratory sequelae of extreme prematurity. The role of genetic factors in its occurrence is suspected for several years.
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In a work coordinated by Pr Delacourt (INSERM U955, Creteil, France), Alice Hadchouel identifies SPOCK2 as a major susceptibility gene for the disease. Two gene variants (polymorphisms) are associated to a 3 to 4-fold higher risk of bronchopulmonary dysplasia in premature neonates. The results obtained in a french population are replicated in an independent Finnish population, reinforcing the role of this gene in the occurrence of the disease. The authors also demonstrate that SPOCK2 is strongly expressed during alveolar growth. Thus, this work identifies new pathophysiologic mechanisms for bronchopulmonary dysplasia, and may allow the development of new therapeutic approaches.
Identification of SPOCK2 as a Susceptibility Gene for Bronchopulmonary Dysplasia.
Hadchouel A, Durrmeyer X, Bouzigon E, Incitti R, Huusko J, Jarreau PH, Lenclen R, Demenais F, Franco-Montoya ML, Layouni I, Patkai J, Bourbon J, Hallman M, Danan C, Delacourt C.
Am J Respir Crit Care Med. 2011 Aug 11.
